Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2018
Resolution of virus infections depends on the priming of virus-specific CD8+ T cells by dendritic cells (DC). While this process requires major histocompatibility complex (MHC) class I-restricted antigen presentation by DC, the relative contribution to CD8+ T cell priming by infected DC is less clear. We have addressed this question in the context of a peripheral infection with herpes simplex virus 1 (HSV). Assessing the endogenous, polyclonal HSV-specific CD8+ T cell response, we found that effective in vivo T cell priming depended on the presence of DC subsets specialized in cross-presentation, while Langerhans cells and plasmacytoid DC were dispensable. Utilizing a novel mouse model that ..View full abstract
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Our research is supported by the National Health and Medical Research Council of Australia. P. Whitney is supported by an Overseas Biomedical Fellowship (NHMRC) and a MDHS Faculty Fellowship (University of Melbourne). T. Gebhardt is supported by a fellowship from the Sylvia and Charles Viertel Charitable Foundation. D. Tscharke is supported by a Senior Research Fellowship (NHMRC).