Journal article
Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study
F Wu, M Juonala, N Pitkänen, A Jula, T Lehtimäki, MA Sabin, K Pahkala, N Hutri-Kähönen, M Kähönen, T Laitinen, JSA Viikari, CG Magnussen, OT Raitakari
Annals of Medicine | TAYLOR & FRANCIS LTD | Published : 2018
Abstract
Objectives: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood. Materials and methods: This was a 31-year follow-up study of 2300 participants aged 3–18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life. Results: High serum 25O..
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Awarded by Yrjö Jahnssonin Säätiö
Funding Acknowledgements
The Young Finns Study has been financially supported by the Academy of Finland: grant Nos. 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi) and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility Area of Kuopio, Tampere and Turku University Hospitals (grant No. X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; and Diabetes Research Foundation of Finnish Diabetes Association. This study was supported by a grant from the National Health and Medical Research Council Project Grant (APP1098369). CGM was supported by a National Heart Foundation of Australia Future Leader Fellowship (100849).