Journal article

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

Anushka N Samudra, Karen M Dwyer, Carly Selan, Susanna Freddi, Lisa Murray-Segal, Mandana Nikpour, Michael J Hickey, Karlheinz Peter, Simon C Robson, Maithili Sashindranath, Peter J Cowan, Harshal H Nandurkar

JOURNAL OF AUTOIMMUNITY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

Abstract

OBJECTIVE: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder of young adults associated with devastating pregnancy complications (recurrent miscarriages, preeclampsia and low birth weight) and vascular complications including thrombosis. The key components implicated in pathogenesis of APS are the complement cascade and tissue factor (TF) activity causing inflammation and coagulation. Purinergic signalling involving catabolism of ATP to adenosine by cell-surface enzymes CD39 and CD73 has anti-inflammatory and anti-thrombotic effects. We studied whether activities of CD39 and CD73 are important in preventing the development of miscarriages in APS. METHODS: We studied frequency..

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Grants

Awarded by NHMRC


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

This work was supported by NHMRC Project Grant 566705 (KD, PC and HN). We acknowledge assistance from the staff at Bio-resources Centre, St. Vincent's Hospital for animal husbandry and Jelena Kezic of the Monash Histology platform for assistance with Histology. The authors acknowledge Monash Micro Imaging, Monash University, for the provision of instrumentation, training and technical support.