Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

S Ramanathan; S Mohammad; E Tantsis; TK Nguyen; V Merheb; VSC Fung; OB White; S Broadley; J Lechner-Scott; S Vucic; APD Henderson; MH Barnett; SW Reddel; F Brilot; RC Dale; P Andrews; J Barton; J Burrow; H Butzkueven; A Cairns; S Calvert; P Caruana; S Chelakkadan; D Clark; C Fraser; J Freeman; D Gill; P Grattan-Smith; S Gupta; T Hardy; K Kothur; S Ling; J Lopez; S Malone; M Marriott; M Nosadini; G O'grady; C Orr; R Ouvrier; J Parratt; E Patrick; D Pilli; D Riminton; K Riney; V Rodriguez-Casero; M Ryan; I Scheffer; U Shah; N Shuey; C Spooner; G Subramanian; F Tea; T Thomas; J Thompson; C Troedson; T Ware; R Webster; C Yiannikas; E Yiu; A Zou

Conference Proceedings

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

S Ramanathan, S Mohammad, E Tantsis, TK Nguyen, V Merheb, VSC Fung, OB White, S Broadley, J Lechner-Scott, S Vucic, APD Henderson, MH Barnett, SW Reddel, F Brilot, RC Dale, P Andrews, J Barton, J Burrow, H Butzkueven, A Cairns Show all

Journal of Neurology Neurosurgery and Psychiatry | BMJ PUBLISHING GROUP | Published : 2018

DOI: 10.1136/jnnp-2017-316880

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Abstract

Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. Methods We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. Results The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical ep..

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Eppie Yiu Author

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Awarded by National Science Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) (Australia), the Petre Foundation (Australia), Multiple Sclerosis Research Australia (MSRA) (Australia), the National Blood Authority IVIg grant (Australia), the Brain Foundation and the Sydney Research Excellence Initiative 2020 Neuroimmunology Group (University of Sydney, Australia).