Journal article
The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults
JS Graves, LF Barcellos, S Simpson, A Belman, R Lin, BV Taylor, AL Ponsonby, T Dwyer, L Krupp, E Waubant, IAF van der Mei
Multiple Sclerosis and Related Disorders | ELSEVIER SCI LTD | Published : 2018
Abstract
Background: While common variant non-HLA (human leukocyte antigen) alleles have been associated with MS risk, their role in disease course is less clear. We sought to determine whether established multiple sclerosis (MS) genetic susceptibility factors are associated with relapse rate in children and an independent cohort of adults with MS. Methods: Genotyping was performed for 182 children with MS or clinically isolated syndrome with high risk for MS from two Pediatric MS Centers. They were prospectively followed for relapses. Fifty-two non-HLA MS susceptibility single nucleotide polymorphisms (SNPs) were evaluated for association with relapse rate. Cox regression models were adjusted for se..
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Awarded by National Institutes of Health
Funding Acknowledgements
We express our gratitude to the patients and families who participated in this research. We acknowledge support for this work from the NIH (R01NS071463, PI Waubant) and from the Race to Erase MS (PI Graves).