Journal article
Brain microbleeds, anticoagulation, and hemorrhage risk: Meta-analysis in stroke patients with AF
A Charidimou, C Karayiannis, TJ Song, DN Orken, V Thijs, R Lemmens, J Kim, SM Goh, TG Phan, C Soufan, RV Chandra, LA Slater, S Haji, V Mok, S Horstmann, KT Leung, Y Kawamura, N Sato, N Hasebe, T Saito Show all
Neurology | Published : 2017
Abstract
Objectives: To assess the association between cerebral microbleeds (CMBs) and future spontaneous intracerebral hemorrhage (ICH) risk in ischemic stroke patients with nonvalvular atrial fibrillation (AF) taking oral anticoagulants. Methods: This was a meta-analysis of cohort studies with.50 patients with recent ischemic stroke and documented AF, brain MRI at baseline, long-term oral anticoagulation treatment, and ≥6 months of follow-up. Authors provided summary-level data on stroke outcomes stratified by CMB status. We estimated pooled annualized ICH and ischemic stroke rates from Poisson regression. We calculated odds ratios (ORs) of ICH by CMB presence/absence, ≥5 CMBs, and CMB topography (..
View full abstract