Journal article
Elevated airway liquid volumes at birth: A potential cause of transient tachypnea of the newborn
EV McGillick, K Lee, S Yamaoka, AB Te Pas, KJ Crossley, MJ Wallace, MJ Kitchen, RA Lewis, LT Kerr, P DeKoninck, J Dekker, M Thio, ARA McDougall, SB Hooper
Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2017
Abstract
Excessive liquid in airways and/or distal lung tissue may underpin the respiratory morbidity associated with transient tachypnea of the newborn (TTN). However, its effects on lung aeration and respiratory function following birth are unknown. We investigated the effect of elevated airway liquid volumes on newborn respiratory function. Near-term rabbit kittens (30 days gestation; term ~32 days) were delivered, had their lung liquid-drained, and either had no liquid replaced (control; n = 7) or 30 ml/kg of liquid re-added to the airways [liquid added (LA); n = 7]. Kittens were mechanically ventilated in a plethysmograph. Measures of chest and lung parameters, uniformity of lung aeration, and a..
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Awarded by Australian Research Council
Funding Acknowledgements
This research was supported by a National Health and Medical Research Council (NHMRC) Program Grant (APP113902) and the Victorian Government's Operational Infrastructure Support Program. We acknowledge travel funding provided by the International Synchrotron Access Program (ISAP) managed by the Australian Synchrotron and funded by the Australian Government (ISAP11508; L. T. Kerr and S. B. Hooper). E. V. McGillick was supported by a Monash University Bridging Postdoctoral Fellowship (BPF17-0066). S. B. Hooper was supported by an NHMRC Principal Research Fellowship (APP1058537). A. B. te Pas was the recipient of a Vidi grant, The Netherlands Organization for Health Research and Development (ZonMw), part of the Innovational Research Incentives Scheme Veni-Vidi-Vici (NWO-Vidi 2015/2016). M. J. Kitchen was supported by an ARC Australian Research Fellowship (Grant no. FT160100454).