Journal article

Human Hepatocellular Carcinomas With a Periportal Phenotype Have the Lowest Potential for Early Recurrence After Curative Resection

Romain Desert, Florian Rohart, Frederic Canal, Marie Sicard, Mireille Desille, Stephanie Renaud, Bruno Turlin, Pascale Bellaud, Christine Perret, Bruno Clement, Kim-Anh Le Cao, Orlando Musso

Hepatology | WILEY | Published : 2017


Hepatocellular carcinomas (HCCs) exhibit a diversity of molecular phenotypes, raising major challenges in clinical management. HCCs detected by surveillance programs at an early stage are candidates for potentially curative therapies (local ablation, resection, or transplantation). In the long term, transplantation provides the lowest recurrence rates. Treatment allocation is based on tumor number, size, vascular invasion, performance status, functional liver reserve, and the prediction of early (<2 years) recurrence, which reflects the intrinsic aggressiveness of the tumor. Well-differentiated, potentially low-aggressiveness tumors form the heterogeneous molecular class of nonproliferative ..

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University of Melbourne Researchers


Awarded by Agence Nationale de la Recherche

Awarded by Fondation Recherche Medicale

Funding Acknowledgements

Supported by INSERM, Universite de Rennes 1, Region Bretagne (VALCIPRE), Agence Nationale de la Recherche (ANR-11-ISV1-0001), Institut National du Cancer (WntHCC), Fondation Recherche Medicale (ING20121226393), Ligue Nationale Contre le Cancer (Comite des Cotes d'Armor), Feder, Contrat de Plan Etat Region 2007-2013, and projet Canceropole.