Journal article
The aspirin in reducing events in the elderly trial: Statistical analysis plan
R Wolfe, AM Murray, RL Woods, B Kirpach, D Gilbertson, RC Shah, MR Nelson, CM Reid, ME Ernst, J Lockery, GA Donnan, J Williamson, JJ McNeil
International Journal of Stroke | Published : 2018
Abstract
Rationale: Aspirin has positive and negative effects on a number of age-related chronic conditions and there is uncertainty regarding its role in primary prevention in people aged 70 years and over. Aims: To assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy older participants. Design: A double-blind, randomized, placebo-controlled primary prevention trial undertaken in Australia and the United States with careful adjudication of endpoints including stroke. Study outcome: In Australia 16,703 individuals were recruited through general practices across five states and territories, and in the United States, 2411 par..
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Awarded by National Institutes of Health
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (grant number U01AG029824); the National Health and Medical Research Council of Australia (grant numbers 334047 and 1127060); Monash University (Australia); and the Victorian Cancer Agency (Australia).