Journal article

Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in US military veterans: Results from the National Health and Resilience in Veterans Study

Natalie P Mota, Shizhong Han, Ilan Harpaz-Rotem, Paul Maruff, John H Krystal, Steven M Southwick, Joel Gelernter, Robert H Pietrzak

DEPRESSION AND ANXIETY | WILEY | Published : 2018

Abstract

BACKGROUND: Previous research examining the association between apolipoprotein E (APOE) gene polymorphism and risk for posttraumatic stress disorder (PTSD) has been inconsistent due to the use of small and select samples. This study examined the relation between APOE genotype and PTSD symptoms in two nationally representative samples of U.S. military veterans. The potential effect of cumulative trauma burden and social support in moderating this association was also evaluated. METHODS: The main sample consisted of 1,386 trauma-exposed European American (EA) veterans (mean age: 62-63 years) who participated in the National Health and Resilience in Veterans Study (NHRVS) in 2011. The independe..

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University of Melbourne Researchers

Grants

Awarded by National Institute on Alcohol Abuse and Alcoholism grant


Awarded by National Center for Advancing Translational Science grants


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM


Funding Acknowledgements

The U.S. Department of VA supported this work through its support of the VA National Center for PTSD and the Consortium to Alleviate PTSD. Dr. Krystal received additional support from a National Institute on Alcohol Abuse and Alcoholism grant (2P50AA012870-14) and National Center for Advancing Translational Science grants (UL1RR024139, principal investigator: R. Sherwin; UH2TR000960, principal investigator: Dr. Krystal). No author has any relevant conflict of interest to disclose.