Association between treatment planning and delivery factors and disease progression in prostate cancer radiotherapy: Results from the TROG 03.04 RADAR trial
Marco Marcello, Martin Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, David Joseph, James Denham
Radiotherapy and Oncology | ELSEVIER IRELAND LTD | Published : 2018
BACKGROUND AND PURPOSE: To evaluate the impact of treatment planning and delivery factors on treatment outcome as measured by post-treatment disease progression. MATERIALS AND METHODS: Accruing 813 external beam radiotherapy participants during 2003-2007, the RADAR trial collected a comprehensive range of clinical treatment factor data for each participant. Both the Fine and Gray competing risks modelling and the Kaplan-Meier (KM) analysis were undertaken to determine the impact of these factors on local-composite progression (LCP), with 709 participants available for analysis. RESULTS: Participants with treatments involving 7 or more beams experienced significantly higher incidence of LCP, ..View full abstract
Awarded by Australian National Health and Medical Research Council
We acknowledge funding from the Australian National Health and Medical Research Council (grants 300705, 455521, 1006447, 1077788), the Hunter Medical Research Institute, the Health Research Council (New Zealand), the University of Newcastle, the Calvary Mater Newcastle, Abbott Laboratories and Novartis Pharmaceuticals. We gratefully acknowledge the support of the Sir Charles Gairdner Hospital, Rachel Kearvell, the 'Elvis' study team including Kristie Harrison, participating RADAR centres, the Trans-Tasman Radiation Oncology Group, Ben Hooton and Elizabeth van der Wath.