Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment
Kar Wai Tan, Maximilien Evrard, Muly Tham, Michelle Hong, Caleb Huang, Masashi Kato, Armelle Prevost-Blondel, Emmanuel Donnadieu, Lai Guan Ng, Jean-Pierre Abastado
ONCOIMMUNOLOGY | TAYLOR & FRANCIS INC | Published : 2015
The infiltration of T lymphocytes within tumors is associated with better outcomes in cancer patients, yet current understanding of factors that influence T-lymphocyte infiltration into tumors remains incomplete. In our study, Temozolomide (TMZ), a chemotherapeutic drug used to treat metastatic melanoma, induced T-cell infiltration into transplanted melanoma and into genitourinary (GU) tumors in mice developing spontaneous melanoma. In contrast, TMZ treatment did not increase T-cell infiltration into cutaneous tumors, despite similar increases in the expression of the (C-X-C) chemokines CXCL9 and CXCL10 in all sites after TMZ exposure. Our findings reveal that the matrix architecture of the ..View full abstract
Awarded by Grants-in-Aid for Scientific Research
This research was funded by SIgN, A*STAR, Singapore. The authors declare that no competing financial interests or conflicts exist.