Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D
Kar Wai Tan, Shu Zhen Chong, Fiona HS Wong, Maximilien Evrard, Sandra Min-Li Tan, Jo Keeble, DM Kemeny, Lai Guan Ng, Jean-Pierre Abastado, Veronique Angeli
BLOOD | AMER SOC HEMATOLOGY | Published : 2013
Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes are known to drive lymphangiogenesis. In this study, we show that neutrophils recruited to sites of inflammation can also coordinate lymphangiogenesis. In the absence of B cells, intranodal lymphangiogenesis induced during prolonged inflammation as a consequence of immunization is dependent on the accumulation of neutrophils. When neutrophils are depleted in wild-type mice developing skin inflammation in response to immunization or contact hypersensitization, lymphangiogenesis is decreased and local inflammation is increased. We demonstr..View full abstract
This work was supported by a Singapore Ministry of Education ACRF Tier 1, National Research Foundation, and Biomedical Research Council grant to Veronique Angeli.