Cortisol limits selected actions of synthetic glucocorticoids in the airway epithelium
Danica Prodanovic, Christine R Keenan, Shenna Langenbach, Meina Li, Qianyu Chen, Michael J Lew, Alastair G Stewart
FASEB JOURNAL | FEDERATION AMER SOC EXP BIOL | Published : 2018
Cortisol, a physiologic glucocorticoid (GC), is essential for growth and differentiation of the airway epithelium. Epithelial function influences inflammation in chronic respiratory diseases. Synthetic GCs, including inhaled corticosteroids, exert anti-inflammatory effects in airway epithelium by transactivation of genes and by inhibition of proinflammatory cytokine release. We examined the effect of cortisol on the actions of synthetic GCs in the airway epithelium, demonstrating that cortisol acts like a partial agonist at the GC receptor (GR), limiting GC-induced GR-dependent transcription in the BEAS-2B human bronchial epithelial cell line. Cortisol also limited the inhibition of granuloc..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
This work was supported by Asthma Australia and the National Health and Medical Research Council (NHMRC) Grant 1059665. The authors declare no conflicts of interest.