Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma
AA Al-Khan, HJ Gunn, MJ Day, M Tayebi, SD Ryan, CA Kuntz, ES Saad, SJ Richardson, JA Danks
JOURNAL OF COMPARATIVE PATHOLOGY | ELSEVIER SCI LTD | Published : 2017
Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal model to study human OS is essential to elucidate the pathogenesis of the disease. This study aimed to validate canine OS as a model for the human disease by evaluating immunohistochemically the expression of markers known to be important in human OS. The immunohistochemical panel included vimentin, alkaline phosphatase (ALP), desmin, S100, neuron-specific enolase (NSE), runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 4 (BMP4). Immunoh..View full abstract
The authors acknowledge funding provided by the Ministry of Higher Education, Sultanate of Oman, and by the School of Health and Biomedical Sciences, RMIT University. We thank A. Barimah for his assistance.