Journal article

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Inma M Berenjeno, Roberto Pineiro, Sandra D Castillo, Wayne Pearce, Nicholas McGranahan, Sally M Dewhurst, Valerie Meniel, Nicolai J Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria ER Parker, Karen G Montgomery, Larissa S Moniz, Cheryl L Scudamore, Wayne A Phillips, Robert K Semple Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2017

Grants

Awarded by EU Marie Curie


Awarded by EMBO


Awarded by Ministry of Economy and Innovation (Spain)


Awarded by Catalan Government


Awarded by People Programme (Marie Curie Actions) from the European Union's Seventh Framework Programme FP7 (REA)


Awarded by European Regional Development Fund under the integrated Project of Excellence


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Wellcome Trust


Awarded by Medical Research Council


Awarded by Cancer Research UK


Awarded by BBSRC


Awarded by NovoNordisk Foundation


Awarded by Biotechnology and Biological Sciences Research Council


Awarded by Novo Nordisk Fonden


Awarded by Rosetrees Trust


Awarded by The Francis Crick Institute


Funding Acknowledgements

We thank Susana Godinho for feedback and experimental advice, Maria Whitehead for assistance in the writing of the manuscript, Romain Galmes and Elena Lopez-Guadamillas for experimental help, members of the Cell Signalling Group for critically reading the manuscript and Susan M. Dymecki for the Flpe-ER<SUP>T2</SUP> mice. We are grateful to the human subjects who provided primary cells for this study. Personal fellowships were from EU Marie Curie (PIEF-GA-2008-219945; to IMB), EMBO (ALTF 165-2013; to S.C.) and the Ong Hin Tiang & Ong Sek Pek Foundation, Malaysia (to E.L.). M.G. was supported by the Ministry of Economy and Innovation (Spain) (SAF2014-59950-P), the Catalan Government (2014-SGR-725), the People Programme (Marie Curie Actions) from the European Union's Seventh Framework Programme FP7/2007-2013 (REA grant agreement 317250), the Institute of Health Carlos III and the European Regional Development Fund under the integrated Project of Excellence no. PIE13/00022 (ONCOPROFILE). W.A.P. was supported by the National Health and Medical Research Council (NHMRC) of Australia (project grant No. 1080491). V.E.R.P. was supported by the Wellcome Trust (097721/Z/11/Z). R.K.S. is supported by the Wellcome Trust (WT098498), the Medical Research Council (MRC_MC_UU_12012/5). V.M. and A.C. were supported by Cancer Research UK (C1295/A15937). S.S is supported by BBSRC (BB/J00989X/1) and Wellcome Trust Senior Investigator Award (103788/Z/14/Z). C.S. is a senior Cancer Research UK clinical research fellow and is funded by Cancer Research UK (TRACERx), the CRUK Lung Cancer Centre of Excellence, Stand Up 2 Cancer (SU2C), the Rosetrees Trust, NovoNordisk Foundation (ID 16584), the Prostate Cancer Foundation, the Breast Cancer Research Foundation, the European Research Council (THESEUS) and National Institute for Health Research University College London Hospitals Biomedical Research Centre. B.V. is supported by Cancer Research UK (C23338/A15965) and the UK NIHR University College London Hospitals Biomedical Research Centre.