The Role of the Plasma Membrane Redox System in the Pathogenesis of Alzheimer's Disease

Abstract

Biological ageing is characterised by prolonged cellular damage over the lifespan, which results from oxidative stress processes that are implicated in both the initiation and progression of age-related disorders such as Alzheimer’s disease (AD). Recently, the role of the plasma membrane redox system, which consists of at least three major components: the lipophilic antioxidants (Coenzyme Q (CoQ) and α-tocopherol), the intracellular cytosolic electron donor (NAD(P)H) and membrane-associated quinone reductases (cytochrome b5 reductase and NADH-quinone), in protecting against oxidative stress has come into focus. Research shows that this redox system plays a protective role during mitochondria..