Innate immune initiators and effectors in Helicobacter pylori infection

Abstract

AbstractThis chapter discusses the innate immune responses generated by the host in an attempt to control Helicobacter pylori infection. The roles of host pathogen-recognition molecules in the identification of H. pylori within the gastric mucosa and the downstream signalling events that these molecules trigger are described. Some of the key H. pylori products that facilitate the initiation of inflammation are identified. How these processes result in the production of proinflammatory cytokines, ultimately leading to the development of gastritis within the host, are discussed.