The Association of HMGB1 Gene with the Prognosis of HCC (Retracted Article)

Jianbiao Xiao; Yi Ding; Jing Huang; Qisheng Li; Ying Liu; Wen Ni; Yuqin Zhang; Yanfei Zhu; Longhua Chen; Bin Chen

Journal article

The Association of HMGB1 Gene with the Prognosis of HCC (Retracted Article)

Jianbiao Xiao, Yi Ding, Jing Huang, Qisheng Li, Ying Liu, Wen Ni, Yuqin Zhang, Yanfei Zhu, Longhua Chen, Bin Chen

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.pone.0089097

Abstract

High-mobility group box 1 protein (HMGB1) is an evolutionarily ancient and critical regulator of cell death and survival. HMGB1 is a chromatin-associated nuclear protein molecule that triggers extracellular damage. The expression of HMGB1 has been reported in many types of cancers, but the role of HMGB1 in hepato cellular carcinoma (HCC) is unknown.The aim of this study was to analyze the roles of HMGB1 in HCC progression using HCC clinical samples. We also investigated the clinical outcomes of HCC samples with a special focus on HMBG1 expression. In an immunohistochemical study conducted on 208 cases of HCC, HMGB1 had high expression in 134 cases(64.4%).The HMGB1 expression level did not co..

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University of Melbourne Researchers

Andrew Wise Author

Grants

Awarded by National Natural Science Foundation of China

Awarded by Guangzhou science and technology

Awarded by Guangdong Provincal Science Foundation

Funding Acknowledgements

Grant support: National Natural Science Foundation of China (No. 81101822), Guangzhou science and technology key projects (No. 11C26090521), Guangdong Provincal Science Foundation (No. 10451001002005047, No. S2013010014185). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.