The role of thrombophilia testing in women with adverse pregnancy outcomes

Abstract

Key content Thrombophilias, whether inherited or acquired, have been linked to adverse pregnancy outcomes, such as pre‐eclampsia, placental abruption, fetal growth restriction, stillbirth, thrombosis and recurrent pregnancy loss in many but not all case–control studies. Prospective cohort studies have confirmed that the majority of women who carry inherited thrombophilias do not experience adverse pregnancy outcomes. Thrombophilia testing is expensive and the positive yield of such investigations, in particular with respect to informing management in a subsequent pregnancy, is low. This review critically evaluates the benefit of thrombophilia testing in the obstetric setting and provide..