Journal article
IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation
Stephane Chevrier, Tobias Kratina, Dianne Emslie, David M Tarlinton, Lynn M Corcoran
IMMUNOLOGY AND CELL BIOLOGY | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/icb.2017.71
Abstract
Bcl6 (B-cell lymphoma 6) is a transcriptional repressor and critical mediator of the germinal center reaction during a T-cell-dependent antibody response, where it enables somatic hypermutation of immunoglobulin genes and inhibits terminal differentiation via repression of Blimp1. It can also contribute to the development of diffuse large B-cell lymphoma when expressed inappropriately. Bcl6 regulation is mediated both at the transcriptional and post-transcriptional levels, and in particular a strong signal through the B-cell receptor causes rapid proteasomal degradation of Bcl6. Despite the importance of Bcl6 in both immunity and cancer, little is known about how other extrinsic factors regu..
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Awarded by National Health and Medical Research Council
Awarded by Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme
Funding Acknowledgements
We are grateful to K O'Donnell for advice on GC B-cell phenotypic analysis, to Dr G Belz for influenza infections, to Dr T Johanson for Drosha and Dicer mutant mice and to R Gloury for preparation and culture of T cells. This work was supported by the National Health and Medical Research Council, through Program Grant 1054925 and fellowships to LMC and DMT. SC was supported by a fellowship from the Swiss National Science Foundation. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme Grant 361646.