Classics in Carbohydrate Chemistry and Glycobiology

Abstract

This chapter presents four accounts of interdisciplinary research aimed at the development of carbohydrate-based therapeutics where synthetic chemistry efforts have played a vital role. Different parasite lines are subsequently investigated, revealing that all investigated strains show a very similar series of Glycosyl-phosphatidy-linositol (GPIs). These studies demonstrate that the GPI structure is likely to be conserved among all P. falciparum subtypes, even those isolated from geographically diverse locations, and emphasize the potential for a general antitoxin vaccine. Isolated P. falciparum GPI elicits a range of inflammatory effects, and deacylation by enzymatic or chemical means rende..