Journal article

Early accrual of organ damage in systemic sclerosis: rationale for development of a disease damage index

Tien Tay, Molla Huq, Nava Ferdowsi, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jane Zochling, Jenny Walker, Susanna M Proudman, Mandana Nikpour

JOURNAL OF SCLERODERMA AND RELATED DISORDERS | SAGE PUBLICATIONS LTD | Published : 2017

Abstract

Introduction: Systemic sclerosis (SSc) is characterized by irreversible organ damage rather than fluctuating disease activity. However, there is no validated measure of damage in SSc. We aimed to quantify the accrual of organ damage in patients with early SSc. Methods: Patients enrolled in the Australian Scleroderma Cohort Study with less than 2 years of SSc since the onset of the first non-Raynaud’s symptom were included. Organ damage was defined by a group of six experts as substantial and permanent loss of organ function due to SSc. Results: We identified 278 patients with early SSc. Among these, 38% had diffuse SSc. Damage was more common in the diffuse than in the limited disease subtyp..

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Grants

Awarded by NHMRC Clinical Research Fellowship


Funding Acknowledgements

Australian Scleroderma Interest Group (ASIG)/Scleroderma Australia fellowship (TT, NF), NHMRC Clinical Research Fellowship APP1071735 (MN) and University of Melbourne David Bickart Fellowship (MN). The Australian Scleroderma Interest Group receives research support from Actelion, Bayer, CSL, Pfizer, GSK, St. Vincent's Research Endowment Fund, Scleroderma Australia and-Arthritis Australia.