Quantification of motor speech in primary progressive aphasia and frontotemporal dementia

Abstract

Frontotemporal dementia (FTD) and primary progressive aphasia (PPA) are two groups of related disorders which are classified into the behavioural (bvFTD), semantic (svPPA), nonfluent/agrammatic (nfvPPA) and logopaenic (lvPPA) variants. Each variant presents with characteristic impairments of communication or behaviour, and the defining features of the syndromes are under ongoing debate in the literature. Researchers and clinicians usually assess speech with listener-based rating scales, which pose a challenge for identifying subtle changes to speech. Objective measures of speech may therefore improve characterisation of speech impairments in the literature and assist in clinical diagnosis an..