Journal article
Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
LM Lindqvist, K Tandoc, I Topisirovic, L Furic
Current Opinion in Genetics and Development | CURRENT BIOLOGY LTD | Published : 2018
Open access
Abstract
Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.
Grants
Awarded by Fonds de Recherche du Québec - Santé
Funding Acknowledgements
Due to the brevity of the format we apologize to the colleagues whose work we did not reference. We thank all the members of our labs for their hard work. Many thanks to Laura Hulea and Oro Uchenunu for proof-reading the manuscript. LF is supported by the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007) and Cancer Australia grant (CA 1084546). This work was made possible through Independent Research Institutes Infrastructure Support Scheme Grant (361646) from the Australian National Health and Medical Research Council and a Victorian State Government Operational Infrastructure Support Grant to The Walter & Eliza Hall Institute of Medical Research (L.M.L.). I.T. is a Junior 2 Research Scholars of the Fonds de Recherche du Quebec - Sante (FRQ-S) and the work in his lab is supported in part by grants from Canadian Institutes of Health Research (PJT-148603), National Institutes of Health (CA202021-01-A1) and Terry Fox New Frontiers Program in Cancer (TFRI 242115).