Journal article
Stress hormones and verbal memory in young people over the first 12 weeks of treatment for psychosis
KA Allott, HP Yuen, CF Bartholomeusz, M Rapado-Castro, C Phassouliotis, F Butselaar, SJ Wood, TM Proffitt, G Savage, LJ Phillips, S Bendall, C Markulev, RLEP Reniers, C Pantelis, L Baldwin, PD McGorry, B Garner
Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2018
Abstract
Aims Memory impairment in psychosis may be mediated through detrimental effects of hypothalamic-pituitary-adrenal (HPA) axis function. This study prospectively investigated the relationship between cortisol, sulphate dehydroepiandrosterone (DHEA(S) and cortisol: DHEA(S) ratio and memory in 35 first-episode psychosis (FEP) patients during the first 12 weeks of treatment and 23 healthy controls (HC). Methods Morning blood sampling and tests of attention, working memory and verbal memory occurred at baseline and 12-week follow-up. Results FEP and HC groups did not significantly differ in levels of cortisol, DHEA(S) or their ratio at baseline or over 12-weeks. The FEP group performed significant..
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Awarded by Fundación Alicia Koplowitz
Funding Acknowledgements
This work was supported by the Colonial Foundation and Orygen, The National Centre of Excellence in Youth Mental Health. KA is supported by a Ronald Philip Griffiths Fellowship from the Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne. MR-C is a Research Fellow and was supported by a Sara Borrell Health Research Fellowship from the Institute of Health Carlos III, Spanish Ministry of Economy and Competitiveness, an Alicia Koplowitz Research Grant, an Alicia Koplowitz Short-Term Visiting Fellowship from the Alicia Koplowitz Foundation, an IiSGM Fellowship Award for Short-Term Placements from the Health Research Institute from the Hospital Gregorio Marafion (IiSGM) (Madrid, Spain) and a NARSAD independent investigator Grant (# 24628).