Journal article

Living systematic reviews: 3. Statistical methods for updating meta-analyses.

Mark Simmonds, Georgia Salanti, Joanne McKenzie, Julian Elliott, undefined Living Systematic Review Network

Journal of Clinical Epidemiology | Published : 2017


A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results may change at later updates. If the review is used in a decision-making context, more caution may be needed. When using standard meta-analysis methods, the chance of incorrectly concluding that any updated meta-analysis is statistically significant when there is no effect (the type I error) increases rapidly as more updates are performed. Inaccurat..

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University of Melbourne Researchers


Awarded by Medical Research Council

Awarded by National Centre for the Replacement, Refinement and Reduction of Animals in Research