Journal article

Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand

Robyn S Lee, Torsten Seemann, Helen Heffernan, Jason C Kwong, Anders Goncalves da Silva, Glen P Carter, Rosemary Woodhouse, Kristin H Dyet, Dieter M Bulach, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2018

Abstract

Background: Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the genomic epidemiology of gonorrhoea in the Western Pacific Region, where the incidence of gonorrhoea is particularly high. Methods: A population-level study of N. gonorrhoeae in New Zealand (October 2014 to May 2015). Comprehensive susceptibility testing and WGS data were obtained for 398 isolates. Relatedness was inferred using phylogenetic trees, and pairwise core SNPs. Mutations and genes known to be associated with resistance were identified, and correlated with phenotype. Results: Eleven clusters were identified. In six of these clusters, >25% of isolates wer..

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Grants

Awarded by Canadian Institutes of Health Research


Awarded by National Health and Medical Research Council, Australia


Awarded by National Health and Medical Research Council


Funding Acknowledgements

R. S. L. is supported by a Fellowship from the Canadian Institutes of Health Research (Funding Reference Number 152448). B. P. H. has a Practitioner Fellowship from the National Health and Medical Research Council, Australia (GNT1105905). J. C. K. is supported by a postgraduate scholarship from the National Health and Medical Research Council (GNT1074824). D. A. W. is supported by an Early Career Fellowship, also from the National Health and Medical Research Council (GNT1123854). This study was funded by the Ministry of Health of New Zealand. The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Victorian Government, Australia.