Journal article
Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men
AJ Trewin, I Levinger, L Parker, CS Shaw, FR Serpiello, MJ Anderson, GK McConell, DL Hare, NK Stepto
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Obesity, sedentary lifestyle and aging are associated with mitochondrial dysfunction and impaired insulin sensitivity. Acute exercise increases insulin sensitivity in skeletal muscle; however, whether mitochondria are involved in these processes remains unclear. The aim of this study was to investigate the effects of insulin stimulation at rest and after acute exercise on skeletal muscle mitochondrial respiratory function (JO2) and hydrogen peroxide emission (JH2O2), and the associations with insulin sensitivity in obese, sedentary men. Nine men (means ± SD: 57 ± 6 years; BMI 33 ± 5 kg.m2) underwent hyperinsulinemic-euglycemic clamps in two separate trials 1–3 weeks apart: one under resting ..
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Funding Acknowledgements
This research was funded by the Victoria University Research Development Grant Scheme (I.L., D.L.H. and G.K.M.) This funding was from the authors institution and they had no input into study design and data analysis. They have no embargo on publication of results. Two authors received funding to support their salaries to undertake this investigator initiated research. I.L. is a Heart Foundation Future Leader Fellow (ID No.100040). N.K.S. was supported by the Australian Government through the National Collaborative Research Network Grant Scheme.