Journal article

Cognitive impairment in epilepsy: the role of reduced network flexibility

Chris Tailby, Magdalena A Kowalczyk, Graeme D Jackson

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | WILEY | Published : 2018

Abstract

Objective: The dominant model of cognitive impairment in focal epilepsy has emphasised structural bases for cognitive deficits. Current theories of cognition in the healthy brain emphasise the importance of the reweighting of brain network interactions in support of task performance. Here, we explore the hypothesis that cognitive deficits in epilepsy arise through abnormalities of dynamic functional network interactions. Method: We studied 19 healthy controls and 37 temporal lobe epilepsy (TLE) patients, using a behavioural measure of verbal fluency (the Controlled Oral Word Association Test) and an fMRI verbal fluency paradigm (Orthographic Lexical Retrieval). Results: Behaviourally, verbal..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC practitioner fellowship


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952 and project grant 1081151) and the Victorian Government Operational Infrastructure Support Program. G.D.J. was supported by an NHMRC practitioner fellowship (1060312).