Biatrial Electrical and Structural Atrial Changes in Heart Failure Electroanatomic Mapping in Persistent Atrial Fibrillation in Humans
Sandeep Prabhu, Aleksandr Voskoboinik, Alex JA McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
JACC Clinical Electrophysiology | ELSEVIER | Published : 2018
OBJECTIVES: This study sought to characterize the biatrial substrate in heart failure (HF) and persistent atrial fibrillation (PeAF). BACKGROUND: Atrial fibrillation (AF) and HF frequently coexist; however, the contribution of HF to the biatrial substrate in PeAF is unclear. METHODS: Consecutive patients with PeAF and normal left ventricular (NLV) systolic function (left ventricular ejection fraction [LVEF] >55%) or idiopathic cardiomyopathy (LVEF ≤45%) undergoing AF ablation were enrolled. In AF, pulmonary vein (PV) cycle length (PVCL) was recorded via a multipolar catheter in each PV and in the left atrial appendage for 100 consecutive cycles. After electrical cardioversion, biatrial elect..View full abstract
This research has been supported in part by the Victorian Government's Operational Infrastructure Funding. Drs. Prabhu, Ling, McLellan, Voskoboinik, Nalliah, and Pathik have received funding from the Australian National Health and Medical Research Council (NHMRC) and/or the National Heart Foundation of Australia. Drs. Prabhu and McLellan have also received funding from the Baker Heart and Diabetes Research Institute (Melbourne, Australia). Drs. Kalman, Lee, and Kistler have been supported in part by the NHMRC. Dr. Kalman has served on the advisory board of Biosense Webster; and has received research and fellowship support from Medtronic, Abbott, and Biosense Webster. All other authors have reported that they have no relationships relevant to this paper to disclose. Katia Zeppenfeld, MD, served as Guest Editor for this article.