Journal article

Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies

David R Skvarc, Michael Berk, Linda K Byrne, Olivia M Dean, Seetal Dodd, Matthew Lewis, Andrew Marriott, Eileen M Moore, Gerwyn Morris, Richard S Page, Laura Gray



Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.


Awarded by NHMRC

Funding Acknowledgements

DRS is supported by the Sydney Parker Smith bequest and Centre for Research Cooperation in Mental Health scholarships. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. OMD has received grant support from the Brain and Behavior Foundation >, Marion and EH Flack Trust, Simons Autism Foundation, Australian Rotary Health, Stanley Medical Research Institute, Deakin University, Brazilian Society Mobility Program, Lilly, NHMRC, Australasian Society for Bipolar and Depressive Disorders and Servier. She has also received in kind support from BioMedica Nutracuticals, NutritionCare and Bioceuticals. All other authors are supported by their affiliated institutions.