Journal article

Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

X Liu, SL Andersen, J Olsen, E Agerbo, V Schlunssen, SC Dharmage, T Munk-Olsen

ALLERGY | WILEY | Published : 2018

Abstract

BACKGROUND: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in this study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. METHODS: We conducted a population-based cohort study using Danish national registers. All live-born singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios (IRRs) of asthma among children born to hypot..

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Grants

Awarded by Danish Council for Independent Research


Awarded by iPSYCH, the Lundbeck Foundation Initiative for Integrative Psychiatric Research


Awarded by Lundbeck Foundation


Funding Acknowledgements

This study is funded by the Danish Council for Independent Research (Project No. DFF-5053-00156B). Munk-Olsen T. and Agerbo E. are supported by iPSYCH, the Lundbeck Foundation Initiative for Integrative Psychiatric Research (R155-2014-1724). Agerbo E. is also supported by Niels Bohr Professorship Grant from the Danish National Research Foundation and the Stanley Medical Research Institute.