Unappreciated diversity within the pool of CD1d-restricted T cells

DG Pellicci; AP Uldrich

Journal article

Unappreciated diversity within the pool of CD1d-restricted T cells

DG Pellicci, AP Uldrich

Seminars in Cell and Developmental Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

DOI: 10.1016/j.semcdb.2017.11.031

Abstract

Studies of lipid reactive CD1d-restricted T cells have focussed on α-galactosylceramide reactive semi-invariant Type I NKT cells, which influence a broad range of immune responses. Much less is known about other CD1d-restricted T cells with respect to TCR diversity, function, the types of antigens they recognize and how they specifically recognize antigens presented by CD1d. In this review, we reflect on recent literature that highlights unexpected complexity within the pool of CD1d-restricted T cells and emphasize how TCR diversity greatly broadens the scope of antigen recognition.

University of Melbourne Researchers

Daniel Pellicci Author

Adam Uldrich Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

DCP is supported by a University of Melbourne CR Roper Fellowship and APU is supported by an ARC Future Fellowship(FT140100278). DGP and APU are supported by NHMRC project grants APP1122890 and APP1083885 and Cancer Council Victoria project grant APP1126866.