Predictors of workplace disability in a premanifest huntington’s disease cohort

Abstract

Huntington’s disease (HD) is an inherited neurodegenerative disease involving motor, cognitive, and psychiatric/ behavioral impairments that will eventually affect work role functioning. Few objective data exist regarding predictors of workplace disability in HD. The authors explored the predictors of work impairment and disability in a cross-sectional cohort of 656 employed, premanifest HD (preHD) individuals. In this cohort—the majority of whom were female, urban-dwelling, married/partnered, and working full-time, with minimal cognitive impairment, good function, minimal motor abnormality, and no indication of significant mental health issues—the number of participants who reported that th..