Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models.
NM Parish, PR Hutchings, L O'Reilly, R Quartey-Papafio, D Healey, P Ozegbe, A Cooke
Immunol Rev | Published : 1995
This chapter aims to describe ways in which autoimmunity can be prevented or reversed and 'self-tolerance' re-established. To this end we have largely restricted our overview to the two main autoimmune disease models with which we are involved, i.e. IDDM in NOD mice and EAT in H-2k mice although, where appropriate and to demonstrate a particular point, other models are mentioned. The chapter has been divided into sections covering protection afforded by 1) transgenes, 2) autoantigen and 3) by reagents targetting T-cell surface molecules. Where established, the mechanism by which protection or tolerance is achieved is described but where, as in most cases, it is unknown the possibilities are ..View full abstract