Association of cerebral amyloid-β Aggregation with cognitive functioning in persons without dementia

WJ Jansen; R Ossenkoppele; BM Tijms; AM Fagan; O Hansson; WE Klunk; WM Van Der Flier; VL Villemagne; GB Frisoni; AS Fleisher; A Lleó; MA Mintun; A Wallin; S Engelborghs; DL Na; G Chételat; JL Molinuevo; SM Landau; N Mattsson; J Kornhuber; O Sabri; CC Rowe; L Parnetti; J Popp; T Fladby; WJ Jagust; P Aalten; DY Lee; R Vandenberghe; CR De Oliveira; E Kapaki; L Froelich; A Ivanoiu; T Gabryelewicz; MM Verbeek; P Sanchez-Juan; H Hildebrandt; V Camus; M Zboch; DJ Brooks; A Drzezga; JO Rinne; A Newberg; A De Mendonça; M Sarazin; GD Rabinovici; K Madsen; MG Kramberger; A Nordberg; V Mok; B Mroczko; DA Wolk; PT Meyer; M Tsolaki; P Scheltens; FRJ Verhey; PJ Visser; D Aarsland; D Alcolea; M Alexander; IS Almdahl; SE Arnold; I Baldeiras; H Barthel; BNM Van Berckel; K Blennow; MA Van Buchem; E Cavedo; K Chen; E Chipi; AD Cohen; S Förster; J Fortea; KS Frederiksen; Y Freund-Levi; O Gkatzima; MF Gordon; T Grimmer; H Hampel; L Hausner; S Hellwig; SK Herukka; P Johannsen; A Klimkowicz-Mrowiec; S Köhler; N Koglin; K Van Laere; M De Leon; V Lisetti; W Maier; J Marcusson; O Meulenbroek; HM Møllergård; JC Morris; A Nordlund; GP Novak; GP Paraskevas; G Perera; O Peters; IHGB Ramakers

Journal article

Association of cerebral amyloid-β Aggregation with cognitive functioning in persons without dementia

WJ Jansen, R Ossenkoppele, BM Tijms, AM Fagan, O Hansson, WE Klunk, WM Van Der Flier, VL Villemagne, GB Frisoni, AS Fleisher, A Lleó, MA Mintun, A Wallin, S Engelborghs, DL Na, G Chételat, JL Molinuevo, SM Landau, N Mattsson, J Kornhuber Show all

JAMA Psychiatry | AMER MEDICAL ASSOC | Published : 2018

DOI: 10.1001/jamapsychiatry.2017.3391

Abstract

IMPORTANCE Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. OBJECTIVE To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive conce..

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