Journal article

The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers

Ka Yee Fung, Paul M Nguyen, Tracy Putoczki

Molecular Immunology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019


Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has been a large effort to dissect the mechanisms required for GI homeostasis, with a major focus on different immune cell populations and the cytokines that they produce. In contrast to T-helper (Th) cells, ILCs respond rapidly to cytokines in their microenvironment in the absence of specific antigens; however, once activated both cell populations have similar effector functions. Two effector cytokines produced by both ILC3 and Th17 cell populations, Interleukin (IL)-17 and IL-22, have taken center stage for their ability to signal directly to GI epithelial cells and..

View full abstract


Awarded by National Health and Medical Research Council Australia (NHMRC)

Awarded by Worldwide Cancer Research project

Funding Acknowledgements

The laboratory of TP is supported by Victorian State Government Operational Infrastructure Support and the National Health and Medical Research Council Australia (NHMRC) project grants APP1080498, and APP1098643, and Worldwide Cancer Research project grant no. 14-1197. PMN was supported by an Australian Postgraduate Scholarship and TP is a Victorian Cancer Agency Fellow, and a WEHI Centenary Fellow.