Journal article

Pathogenesis, Humoral Immune Responses, and Transmission between Cohoused Animals in a Ferret Model of Human Respiratory Syncytial Virus Infection

Kok Fei Chan, Louise A Carolan, Julian Druce, Keith Chappell, Daniel Watterson, Paul Young, Daniil Korenkov, Kanta Subbarao, Ian G Barr, Karen L Laurie, Patrick C Reading

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2018

Abstract

Small-animal models have been used to obtain many insights regarding the pathogenesis and immune responses induced following infection with human respiratory syncytial virus (hRSV). Among those described to date, infections in cotton rats, mice, guinea pigs, chinchillas, and Syrian hamsters with hRSV strains Long and/or A2 have been well characterized, although clinical isolates have also been examined. Ferrets are also susceptible to hRSV infection, but the pathogenesis and immune responses elicited following infection have not been well characterized. Here, we describe the infection of adult ferrets with hRSV Long or A2 via the intranasal route and characterized virus replication, as well ..

View full abstract

Grants

Awarded by RMH Home Lottery grant


Funding Acknowledgements

The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. This study was supported in part by RMH Home Lottery grant GIA-035-2016.