Journal article
A randomised controlled trial comparing high-flow nasal oxygen with standard management for conscious sedation during bronchoscopy
N Douglas, I Ng, F Nazeem, K Lee, P Mezzavia, R Krieser, D Steinfort, L Irving, R Segal
Anaesthesia | WILEY | Published : 2018
DOI: 10.1111/anae.14156
Abstract
Traditional conscious sedation for endobronchial ultrasound procedures places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk. We designed a parallel-group randomised controlled trial of high-flow nasal oxygen at a flow rate of 30–70 l.min−1 via nasal cannulae, compared with standard oxygen therapy at 10 l.min−1 via a bite block in adults planned for conscious sedation for endobronchial ultrasound. The primary outcome was the proportion of patients experiencing desaturation (defined as SpO2 < 90%). Secondary outcomes included oxygen saturation after pre-oxygenation, lowest oxygen saturation during procedure, number of hypoxic episodes, duration of hypoxia, en..
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Funding Acknowledgements
Registered at the Australia and New Zealand Clinical Trials Registry (ACTRN12616001691437) and with the Universal Trial Number U1111-1183-6921. The authors acknowledge the patients, anaesthetists and operators who undertook the procedures, without whom the trial could not have happened, as well as the support of the Departments of Anaesthesia and Pain Medicine and Respiratory Medicine.The trial was supported by the Department of Anaesthesia and Pain Management of the Royal Melbourne Hospital. A novice investigator grant was awarded by the Australian and New Zealand College of Anaesthetists. No other external funding or competing interests declared.