Journal article
A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation
MI Pastrama, S Scheiner, P Pivonka, C Hellmich
Bone | ELSEVIER SCIENCE INC | Published : 2018
Abstract
While bone tissue is a hierarchically organized material, mathematical formulations of bone remodeling are often defined on the level of a millimeter-sized representative volume element (RVE), “smeared” over all types of bone microstructures seen at lower observation scales. Thus, there is no explicit consideration of the fact that the biological cells and biochemical factors driving bone remodeling are actually located in differently sized pore spaces: active osteoblasts and osteoclasts can be found in the vascular pores, whereas the lacunar pores host osteocytes – bone cells originating from former osteoblasts which were then “buried” in newly deposited extracellular bone matrix. We here p..
View full abstractGrants
Awarded by European Research Council
Funding Acknowledgements
Financial support by the European Research Council (ERC), in the framework of the project Multiscale poromicromechanics of bone materials, with links to biology and medicine (project number FP7-257023), is gratefully acknowledged. The first author acknowledges a travel stipend of the Vienna University of Technology (TU Wien), for a research stay at The University of Melbourne, Australia. The continuous cooperation between the Austrian and Australian scientists was also facilitated within COST action MP1005 - From nano to macro biomaterials (design, processing, characterization, modeling) and applications to stem cells regenerative orthopedic and dental medicine (NAMABIO).