Journal article

Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

Giovanni Fiorito, Silvia Polidoro, Pierre-Antoine Dugue, Mika Kivimaki, Erica Ponzi, Giuseppe Matullo, Simonetta Guarrera, Manuela B Assumma, Panagiotis Georgiadis, Soterios A Kyrtopoulos, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Marc Chadeau-Hyam, Silvia Stringhini, Gianluca Severi, Allison M Hodge, Graham G Giles Show all



Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated ..

View full abstract


Awarded by Trinity College Dublin, Dublin, Ireland (European Commission H2020)

Awarded by Swiss National Science Foundation (Ambizione)

Awarded by European Union

Awarded by UK Medical Research Council

Awarded by Australian National Health and Medical Research Council

Awarded by Medical Research Council

Funding Acknowledgements

This research was supported by the 'Lifepath' grant to Paolo Vineis at Imperial College, London, Silvia Polidoro at the HuGeF Foundation, Silvia Stringhini at Lausanne's University Hospital, Mika Kivimaki at University College London, Richard Layte and Cathal McCrory at the Trinity College Dublin, Dublin, Ireland (European Commission H2020 grant, Grant number: 633666). Giovanni Fiorito, Silvia Polidoro, Giuseppe Matullo and Simonetta Guarrera are supported by the Italian Institute for Genomic Medicine (IIGM), Torino, Italy with support from Compagnia di San Paolo. Silvia Stringhini is supported by the Swiss National Science Foundation (Ambizione Grant no PZ00P3_147998). Laura Baglietto is supported by a Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme. Panagiotis Georgiadis and Soterios A. Kyrtopoulos were supported by the European Union grant Envirogenomarkers (Grant number 226756). Mika Kivimaki is supported by the UK Medical Research Council (K013351) and NordForsk. The MCCS component of the work was funded by the Australian National Health and Medical Research Council, including project grant numbers 1011618, 1026892, 1026522, 1050198, 623206, and 1043616, and program grant numbers 209057 and 1074383.