The SPICE III study protocol and analysis plan: a randomised trial of early goal-directed sedation compared with standard care in mechanically ventilated patients
Yahya Shehabi, Andrew B Forbes, Yaseen Arabi, Frances Bass, Rinaldo Bellomo, Suhaini Kadiman, Belinda D Howe, Colin McArthur, Michael C Reade, Ian Seppelt, Jukka Takala, Steve Webb, Matthew P Wise
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2017
Awarded by National Health and Medical Research Council of Australia
Awarded by Health Research Council of New Zealand
SPICE III is conducted on behalf of and endorsed by the Australian and New Zealand Intensive Care Society Clinical Trials Group, managed by the Australian and New Zealand Intensive Care Research Centre at Monash University, and funded by the National Health and Medical Research Council of Australia (project grant no. 1043938), the Health Research Council of New Zealand (project grant no. 14/115) and the National Heart Institute of Malaysia. This report presents the trial protocol and the statistical analysis plan. SPICE III is registered with clinicaltrials.gov (NCT01728558).