Journal article

A Decade of the Protein Corona

Pu Chun Ke, Sijie Lin, Wolfgang J Parak, Thomas P Davis, Frank Caruso

ACS NANO | AMER CHEMICAL SOC | Published : 2017

Abstract

In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the "biocorona", a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.

University of Melbourne Researchers

Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Funding Acknowledgements

This work was supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) and by the Deutsche Forschungsgemeinschaft (DFG, DFG Grant PA 794/25-1). F.C. and T.P.D. acknowledge Australian Laureate Fellowships from the Australian Research Council.