A Decade of the Protein Corona
Pu Chun Ke, Sijie Lin, Wolfgang J Parak, Thomas P Davis, Frank Caruso
ACS NANO | AMER CHEMICAL SOC | Published : 2017
In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the "biocorona", a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.
Related Projects (2)
Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Deutsche Forschungsgemeinschaft (DFG)
This work was supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) and by the Deutsche Forschungsgemeinschaft (DFG, DFG Grant PA 794/25-1). F.C. and T.P.D. acknowledge Australian Laureate Fellowships from the Australian Research Council.