Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

JHY Wu; M Marklund; F Imamura; N Tintle; AV Ardisson Korat; J de Goede; X Zhou; WS Yang; MC de Oliveira Otto; J Kröger; W Qureshi; JK Virtanen; JK Bassett; AC Frazier-Wood; M Lankinen; RA Murphy; K Rajaobelina; LC Del Gobbo; NG Forouhi; R Luben; KT Khaw; N Wareham; A Kalsbeek; J Veenstra; J Luo; FB Hu; HJ Lin; DS Siscovick; H Boeing; TA Chen; B Steffen; LM Steffen; A Hodge; G Eriksdottir; AV Smith; V Gudnason; TB Harris; IA Brouwer; C Berr; C Helmer; C Samieri; M Laakso; MY Tsai; GG Giles; T Nurmi; L Wagenknecht; MB Schulze; RN Lemaitre; KL Chien; SS Soedamah-Muthu; JM Geleijnse; Q Sun; WS Harris; L Lind; J Ärnlöv; U Riserus; R Micha; D Mozaffarian

Journal article

Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

JHY Wu, M Marklund, F Imamura, N Tintle, AV Ardisson Korat, J de Goede, X Zhou, WS Yang, MC de Oliveira Otto, J Kröger, W Qureshi, JK Virtanen, JK Bassett, AC Frazier-Wood, M Lankinen, RA Murphy, K Rajaobelina, LC Del Gobbo, NG Forouhi, R Luben Show all

Lancet Diabetes and Endocrinology | ELSEVIER SCIENCE INC | Published : 2017

DOI: 10.1016/S2213-8587(17)30307-8

Abstract

Background The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled bet..

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University of Melbourne Researchers

Allison Hodge Author

Graham Giles Author

Grants

Awarded by National Human Genome Research Institute

Funding Acknowledgements

Cohort specific funding is outlined in the appendix. Unilever also provided Tufts University (Massachusetts, MA, USA) with a restricted grant ('epidemiological research on circulating polyunsaturated fatty acids in relation to cardiometabolic health within the CHARGE-consortium') to partly support this analysis.