Mapping of functional activity in brain with 18F-fluoro-deoxyglucose.
A Alavi, M Reivich, J Greenberg, P Hand, A Rosenquist, W Rintelmann, D Christman, J Fowler, A Goldman, R MacGregor, A Wolf
Semin Nucl Med | Published : 1981
The efficacy of using the 18F-fluoro-deoxyglucose (18F-DG) for measuring regional cerebral glucose utilization in man during functional activation is demonstrated. Normal male volunteers subjected to sensory stimuli (visual, auditory, tactile) exhibited focal increases in glucose metabolism in response to the stimulus. Unilateral visual hemifield stimulation caused the contralateral striate cortex to become more active metabolically than the striate cortex ipsilateral to the stimulated hemifield. Similarly, stroking of the fingers and hand of one arm with a brush produced an increase in metabolism in the contralateral postcentral gyrus compared to the homologous ipsilateral region. The audit..View full abstract