Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

S Bernatsky; HAV García; JJ Spinelli; P Gaffney; KE Smedby; R Ramsey-Goldman; SS Wang; HO Adami; D Albanes; E Angelucci; SM Ansell; Y WAsmann; N Becker; Y Benavente; SI Berndt; KA Bertrand; BM Birmann; H Boeing; P Boffetta; PM Bracci; P Brennan; AR Brooks-Wilson; JR Cerhan; SJ Chanock; J Clavel; L Conde; KH Cotenbader; DG Cox; W Cozen; S Crouch; AJ De Roos; S De Sanjose; S Di Lollo; WR Diver; A Dogan; L Foretova; H Ghesquières; GG Giles; B Glimelius; TM Habermann; C Haioun; P Hartge; H Hjalgrim; TR Holford; EA Holly; RD Jackson; R Kaaks; E Kane; RS Kelly; RJ Klein; P Kraft; A Kricker; Q Lan; C Lawrence; M Liebow; T Lightfoot; BK Link; M Maynadie; J McKay; M Melbye; TJ Molina; A Monnereau; LM Morton; A Nieters; KE North; AJ Novak; K Offit; MP Purdue; M Rais; J Riby; E Roman; N Rothman; G Salles; G Severi; RK Severson; CF Skibola; SL Slager; A Smith; MT Smith; MC Southey; A Staines; LR Teras; CA Thompson; H Tilly; LF Tinker; A Tjonneland; J Turner; CM Vajdic; RCH Vermeulen; J Vijai; P Vineis; J Virtamo; Z Wang; S Weinstein; TE Witzig; A Zelenetz; A Zeleniuch-Jacquotte; Y Zhang; T Zheng; M Zucca

Journal article

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

S Bernatsky, HAV García, JJ Spinelli, P Gaffney, KE Smedby, R Ramsey-Goldman, SS Wang, HO Adami, D Albanes, E Angelucci, SM Ansell, Y WAsmann, N Becker, Y Benavente, SI Berndt, KA Bertrand, BM Birmann, H Boeing, P Boffetta, PM Bracci Show all

Lupus Science and Medicine | Published : 2017

DOI: 10.1136/lupus-2016-000187

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Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q..

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University of Melbourne Researchers

Prof Melissa Southey Author

Grants

Awarded by Yorkshire Cancer Research

Funding Acknowledgements

Support for individual studies ATBC: The a-Tocopherol, II-Carotene Cancer Prevention Study is supported by the Intramural Research Program of the U.S. National Cancer Institute, National Institutes of Health and by U.S. Public Health Service contract HHSN261201500005C from the National Cancer Institute, Department of Health and Human Services. BC: Canadian Institutes for Health Research (CIHR); Canadian Cancer Society; Michael Smith Foundation for Health Research. CPS-II: The Cancer Prevention Study-II (CPS-II) Nutrition Cohort is supported by the American Cancer Society. Genotyping for all CPS-II samples were supported by the Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics. The authors would also like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention National Program of Cancer Registries and cancer registries supported by the National Cancer Institute Surveillance Epidemiology and End Results programme. ELCCS: Bloodwise (formerly Leukaemia & Lymphoma Research); grant reference 0073. ENGELA: Association pour la Recherche contre le Cancer (ARC), Institut National du Cancer (INCa), Fondation de France, Fondation contre la HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C and HHSN271201100004C. YALE: National Cancer Institute (CA62006); National Cancer Institute (CM 65923).