Osteopontin Is a Strong Predictor of Incipient Diabetic Nephropathy, Cardiovascular Disease, and All-Cause Mortality in Patients With Type 1 Diabetes
Daniel Gordin, Carol Forsblom, Nicolae M Panduru, Merlin C Thomas, Mette Bjerre, Aino Soro-Paavonen, Nina Tolonen, Niina Sandholm, Allan Flyvbjerg, Valma Harjutsalo, Per-Henrik Groop
DIABETES CARE | AMER DIABETES ASSOC | Published : 2014
OBJECTIVE: Osteopontin (OPN) is a multifunctional protein suggested to be a player in the arterial disease of patients with type 2 diabetes. However, its role for complications in patients with type 1 diabetes (T1D) is unknown. We therefore investigated the associations between OPN and diabetic vascular complications and all-cause mortality in patients with T1D. RESEARCH DESIGN AND METHODS: Serum OPN was measured in 2,145 adults with T1D without end-stage renal disease (ESRD; dialysis or transplantation) as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. Data on renal status, cardiovascular disease (CVD), and all-cause mortality during follow-up were verified from medical files, ..View full abstract
Awarded by Academy of Finland
This study was supported by grants from Folkhalsan Research Foundation, Academy of Finland (134379), Helsinki University Central Hospital Research Funds (EVO), the Wilhelm and Else Stockmann Foundation, the Waldemar von Frenckell Foundation, the Liv och Halsa Foundation, the Finnish Medical Society (Finska Lakaresallskapet), the Diabetes Research Foundation, the Nylands Nation Foundation, the Paulo Foundation, the Paavo Nurmi Foundation, the Finnish Medical Foundation, and the Biomedicum Helsinki Foundation.