Journal article
Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
A Soro-Paavonen, AMD Watson, J Li, K Paavonen, A Koitka, AC Calkin, D Barit, MT Coughlan, BG Drew, GI Lancaster, M Thomas, JM Forbes, PP Nawroth, A Bierhaus, ME Cooper, KA Jandeleit-Dahm
Diabetes | AMER DIABETES ASSOC | Published : 2008
DOI: 10.2337/db07-1808
Abstract
OBJECTIVE-Activation of the receptor for advanced glycation end products (RAGE) in diabetic vasculature is considered to be a key mediator of atherogenesis. This study examines the effects of deletion of RAGE on the development of atherosclerosis in the diabetic apoE-/- model of accelerated atherosclerosis. RESEARCH DESIGN AND METHODS-ApoE-/- and RAGE-/-/ apoE-/- double knockout mice were rendered diabetic with streptozotocin and followed for 20 weeks, at which time plaque accumulation was assessed by en face analysis. RESULTS-Although diabetic apoE-/- mice showed increased plaque accumulation (14.9 ± 1.7%), diabetic RAGE-/-/apoE-/- mice had significantly reduced atherosclerotic plaque area ..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
A.S.-P. has received grants from the Academy of Finland, the Orion-Farmos Research Foundation, and the Finnish Cardiovascular Research Foundation. A.K. has received support from Association de Langue Francaise pour l'Etude du Diabete et des Maladies Metaboliques (France). M.T. has received grants from the Juvenile Diabetes Research Foundation (JDRF) Center, NHMRC, National Health Fund (NHF), and the National Institutes of Health (5R0-HL-083452-02); a Career Development Award (NHMRC/Diabetes Australia); and the Kidney Health Australia-Bootle bequest. J.M.F. has received grants from the JDRF Center, NHMRC, NHF, and the National Institutes of Health (5R0-HL-083452-02) and is a recipient of a JDRF career development award. P.P.N. has received grants from the JDRF Center and the Deutsche Forschungs-gemeinschaft (SFB405). A.B. has received a JDRF Center grant. M.E.C. has received grants from the JDRF Center, NHMRC, NHF, and the National Institutes of Health (5R0-HL-083452-02). K.A.J.-D. has received grants from the JDRF Center, NHMRC, NHF, and the National Institutes of Health (5R0-HL-083452-02) and is a recipient of a NHMRC/NHF career development award.