Journal article

Competing-Risk Analysis of ESRD and Death among Patients with Type 1 Diabetes and Macroalbuminuria

Carol Forsblom, Velma Harjutsalo, Lena M Thorn, Johan Waden, Nina Tolonen, Markku Saraheimo, Daniel Gordin, John L Moran, Merlin C Thomas, Per-Henrik Groop

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2011

Abstract

Patients with both type 1 diabetes and CKD have an increased risk of adverse outcomes. The competing risks of death and ESRD may confound the estimates of risk for each outcome. Here, we sought to determine the major predictors of the cumulative incidence of ESRD and pre-ESRD mortality in patients with type 1 diabetes and macroalbuminuria while incorporating the competing risk for the alternate outcome into a Fine-Gray competing-risks analysis. We followed 592 patients with macroalbuminuria for a median of 9.9 years. During this time, 56 (9.5%) patients died and 210 (35.5%) patients developed ESRD. Predictors of incident ESRD, taking baseline renal function and the competing risk for death i..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

The study was supported by grants from the Folkhalsan Research Foundation, the Wilhelm and Else Stockmann Foundation, the Liv och Halsa Foundation, and the Finnish Medical Society (Finska Lakaresallskapet). The skilled technical assistance of our laboratory technicians Maikki Parkkonen, Anna Sandelin, and Jaana Tuomikangas is gratefully acknowledged. Finally, we acknowledge all of the physicians and nurses at each center participating in the collection of patients. The whole FinnDiane Study Group has been previously presented in detail.<SUP>1,5,6</SUP>